PMN:TSX; ARFXF:OTCQB

ProMIS Neurosciences Inc.

The mission of ProMIS Neurosciences is to discover and develop precision medicine therapeutics for best in class treatment of neurodegenerative diseases, in particular, Alzheimer's disease (AD) and ALS. ProMIS Neurosciences' proprietary target discovery engine is based on two, complementary techniques. The Company applies its thermodynamic, computational discovery platforms—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes on the surface of misfolded proteins. ProMIS has identified five target sites on toxic, misfolded strains of amyloid beta, a known root cause of Alzheimer's, and created five antibodies specific to these targets (without targeting amyloid beta monomer or plaque, known to be related to poor efficacy and side effects). Results of prior clinical trials indicate best in class AD therapy should target specifically toxic, misfolded strains of amyloid beta and not the other forms. ProMIS' AD program is uniquely designed and on track to achieve this goal. The Company's lead antibody product, PMN310 is in late preclinical development, with initiation of clinical trials expected in 2019.
PMN:TSX ARFXF:OTCQB

Expert Comments:

The expert brings to the board a deep knowledge of neurodegeneration.
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The focus will be the Canadian company's lead monoclonal antibody candidate.
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The Canadian company's approach to this indication is now twofold.
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Cosme Ordonez, Noble Capital Markets

(5/15/19)
"The progress made in ProMIS Neurosciences Inc.'s Parkinson's program was presented at the 14th International Conference on Alzheimer's and Parkinson's Diseases held in Lisbon, Portugal, from March 26 to 31, 2019. The company was able to showcase results demonstrating the selectivity of anti-alpha synuclein antibodies, which selectively bind to toxic forms of alpha synuclein while sparing the normal form of this protein present in healthy cells."

Clive Maund, CliveMaund.com

(5/12/19)
"ProMIS Neurosciences Inc. has done as expected and is a Buy again here. . .it is now showing signs that it is ready to advance anew, at a time when the broad market is showing signs that it is ready to bounce back after its trade deal shock."

The company cites the recent discontinuation of other firms' clinical programs as proof.
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Cosme Ordonez, Noble Capital Markets

(3/21/19)
"ProMIS Neurosciences Inc. is developing a novel therapeutic approach targeting a completely different molecular target [from Biogen's]. . .in light of Biogen's failure, we believe that ProMIS will emerge as a leader in the Alzheimer's area with a potentially disease modifying therapy. . .the currently deflated share price does not reflect the potential of ProMIS' lead drug and product pipeline."

headshot of André Uddin

André Uddin, Mackie Research Capital

(3/21/19)
"ProMIS Neurosciences Inc. has identified multiple targets for neurodegenerative disorders: an alpha synuclein for Parkinson's, tau for Alzheimer's and SOD1 and TDP43 for amyotrophic lateral sclerosis; we expect the company to outlicense these targets and related candidates. A licensing deal could be forged in Q2/19 or Q3/19 for one of these drug candidates; multiple players are currently at the table."

The biotech was selected to discuss its antibodies that selectively target toxic forms of alpha-synuclein.
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André Uddin, Mackie Research Capital

(3/15/19)
"ProMIS Neurosciences Inc. is to initiate a Phase 1 study with PMN310 in both healthy subjects and prodromal/mild Alzheimer's patients (total n=8) in H2/19; results of this trial are expected in late 2020. Results of Biogen's Phase 3 ENGAGE trial with aducanumab are also expected in 2020; positive ENGAGE results could potentially enable ProMIS to piggyback on that data, enabling it to potentially outlicense PMN310."

Clive Maund, CliveMaund.com

(3/10/19)
"ProMIS Neurosciences Inc. is a biotech stock that is working out well for us. . .the long-term outlook for the company and its stock is excellent."

The Canadian company continues seeking partners to leverage its discovery and development platform.
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This Canadian developer of therapeutics for neurodegenerative diseases bases its opinion, in part, on its own preclinical findings.
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More Expert Comments

Experts Following This Company

Clive Maund – CliveMaund.com
headshot of André Uddin
André Uddin – Mackie Research Capital
John Vandermosten, CFA – Zacks Small-Cap Research

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